5HT2A Receptor Positive Control

General Information

Product

5HT2A Receptor Positive Control

Description

Western Blot Positive Control 5-hydroxytryptamine receptor 2A Antibody

Verified Applications

WB

Immunogen

Purified protein.

Accession #

NCBI:  NP_000612

Physical Properties

Quantity

5 Applications

Volume

Inquire

Form

Western Blot Positive Control

Storage

-20⁰C for long term storage

Application Protocol

Western Blot

1:500

Protein

Uniprot #

P28223

Overview

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca2+ ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.

Molecular Function

G-protein coupled receptor, Host cell receptor for virus entry, Receptor, Transducer

Subcellular Location

Cell Membrane, Cell projection

Expression

Detected in brain cortex. Detected in blood platelets.

Structure

The PDZ domain-binding motif is involved in the interaction with PATJ, CASK, APBA1, DLG1 and DLG4.

Alternative Nomenclature

5 HT2 receptor antibody

5 HT2A antibody

5 hydroxytryptamine receptor 2A antibody

5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled antibody

HTR 2A antibody

HTR2 antibody

serotonin 5-HT-2A receptor antibody

Serotonin receptor 2A antibody