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General Information
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Product
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ARMET Peptide
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Description
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Antigenic Blocking Peptide Mesencephalic astrocyte-derived neurotrophic factor
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Verified Applications
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Immunodepletion, Immunocompetition
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Peptide Description
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Synthetic peptide taken within amino acid region 80-120 on human Mesencephalic astrocyte-derived neurotrophic factor.
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Accession #
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NCBI: NP_006001
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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P55145
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Overview
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Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.
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Molecular Function
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Growth factor
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Subcellular Location
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Secreted, Endoplasmic reticulum, Extracellular space, Nucleus
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Expression
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By endoplasmic reticulum stress.
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Structure
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The N-terminal region may be responsible for neurotrophic activity while the C-terminal region may play a role in the ER stress response.
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Alternative Nomenclature
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Arginine rich mutated in early stage tumors antibody
Arginine rich protein antibody
ARMET antibody
ARP antibody
Manf antibody
Mesencephalic astrocyte derived neurotrophic factor antibody
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ARMET Antibody
ARMET Antibody BIOTIN
ARMET Antibody FITC
ARMET Positive Control
