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General Information
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Product
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D6 Peptide
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Description
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Antigenic Blocking Peptide Atypical chemokine receptor 2
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Verified Applications
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Immmunodepletion, Competition Assay
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Peptide Description
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Synthetic peptide taken within amino acid region 300-378 mouse Atypical chemokine receptor 2 protein.
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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O08707
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Overview
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Controls chemokine levels and localization via high-affinity chemoking binding that is uncoupled from classic liand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells and is required for immature/mature dendritic cells discrimination.
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Molecular Function
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Chemokine Receptor activity; Scavenger receptor activity
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Subcellular Location
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Early endosome; Recycling endosome; Cell membrane; Multi-pass membrane protein
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Expression
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Endothelial cells lining afferent lympatics in dermis and lymph nodes. Also found n subcapsular and medullary sinuses, tonsillar lympatic sinuses and lymphatics in mucosa and submucosa of appendix, small intestine, and large intestine. Experssed in Kapo
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Structure
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C-terminal cytoplasmic tail controls phosphorylation, stability, intracellular trafficking and chemokine scavenging properties.
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Alternative Nomenclature
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ACKR2 antibody
Atypical chemokine receptor 2 antibody
Chemokine binding protein 2 antibody
Chemokine receptor CCR 10 antibody
Chemokine receptor CCR 9 antibody
CMKBR9 antibody
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Atypical Chemokine Receptor D6 Antibody
Atypical Chemokine Receptor D6 Antibody FITC
Atypical Chemokine Receptor D6 Antibody BIOTIN
Atypical Chemokine Receptor D6 Positive Control
