Atypical Chemokine Receptor D6 Positive Control

General Information

Product

D6 Positive Control

Description

Western Blot Positive Control Atypical chemokine receptor 2

Verified Applications

WB

Accession #

NCBI:  NP_001287.2

Physical Properties

Quantity

5 Applications

Volume

Inquire

Form

Western Blot Positive Control in ready to use SDS sample buffer

Storage

-20⁰C for long term storage

Protein

Uniprot #

O00590

Overview

Controls chemokine levels and localization via high-affinity chemoking binding that is uncoupled from classic liand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis.  Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells and is required for immature/mature dendritic cells discrimination.

Molecular Function

Chemokine Receptor activity; Scavenger receptor activity

Subcellular Location

Early endosome; Recycling endosome; Cell membrane; Multi-pass membrane protein

Expression

Endothelial cells lining afferent lympatics in dermis and lymph nodes.  Also found n subcapsular and medullary sinuses, tonsillar lympatic sinuses and lymphatics in mucosa and submucosa of appendix, small intestine, and large intestine.  Experssed in Kapo

Structure

C-terminal cytoplasmic tail controls phosphorylation, stability, intracellular trafficking and chemokine scavenging properties.

Alternative Nomenclature

ACKR2 antibody

Atypical chemokine receptor 2 antibody

Chemokine binding protein 2 antibody

Chemokine receptor CCR 10 antibody

Chemokine receptor CCR 9 antibody

CMKBR9 antibody