Bcl-XL Positive Control

Product no.: PC-BCL2X
$200.00


General Information

 

 

Product

 

Bcl-XL Positive Control

Description

Western Blot Positive Control Bcl-2-like protein 1 Antibody

Verified Applications

WB

Immunogen

Purified Protein


Physical Properties

 

 

Quantity

 

5 Applications

Volume

Inquire

Form

Western Blot Positive Control

Storage

-20C for long term storage


Application Protocol

Western Blot

1:500


Protein

 

Uniprot #

 

Q07817

Overview

Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F1F0 activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release. Isoform Bcl-X(S) promotes apoptosis.

Molecular Function

BH3 domain binding; Identical protein binding; Protein heterodimerization and homodimerization activity; protein kinase binding

Subcellular Location

Mitochondrion inner membrane

Mitochondrion outer membrane

Mitochondrion matrix

Cytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane

Cytoplasm › cytosol

Cytoplasm › cytoskeleton › microtubule organizing center › centrosome

Nucleus membrane ; Single-pass membrane protein ; Cytoplasmic side

Note: After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner. Localizes to the centrosome when phosphorylated at Ser-49.

Expression

Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.

Structure

The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death. The loop between motifs BH4 and BH3 is required for the interaction with NLRP1.

Alternative Nomenclature

Apoptosis regulator Bcl X antibody

B cell lymphoma 2 like antibody

B2CL1_HUMAN antibody

Bcl 2 like 1 protein antibody

Bcl X antibody

Bcl xL antibody

BCL XL/S antibody

Bcl xS antibody

Bcl-2-like protein 1 antibody

Bcl2 Like 1 antibody

Bcl2 related gene antibody

BCL2L antibody

BCLX antibody

PPP1R52 antibody

Protein phosphatase 1 regulatory subunit 52 antibody

   

Protein information supplied by UniProt
 

 

Accessories

Product Note Status Price
Bcl-XL Blocking Peptide Bcl-XL Blocking Peptide
P-BCL2X $155.00 *
Bcl-XL Antibody FITC Bcl-XL Antibody FITC
BCL2X-FITC $375.00 *
Bcl-XL Antibody BIOTIN Bcl-XL Antibody BIOTIN
BCL2X-BIOTIN $375.00 *
Bcl-XL Antibody Bcl-XL Antibody
BCL2X-101AP $285.00 *
Display accessory details