Bile Acid Receptor NR1H4 Antibody BIOTIN

Product no.: NR1H4-BIOTIN
$375.00


General Information

 

 

Product

 

Bile Acid Receptor NR1H4 Antibody BIOTIN

Description

BIOTIN-Conjugated Bile acid receptor / NR1H4 / FXR A3-4 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Huma

Immunogen

Synthetic peptide taken within amino acid region 1-50 on huma Bile acid receptor / NR1H4 / FXR A3-4 protein.


Physical Properties

 

Quantity

 

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

BIOTIN-Conjugated

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20C for long term storage


Application Protocol

 

ELISA

 

1:50,000

Immunoprecipitation

1:200

Western Blot

1:2,500-1:5,000


Protein

 

Uniprot #


Q96RI1

Overview

Ligand-activated transcription factor. Receptor for bile acids (BAs) such as chenodeoxycholic acid (CDCA), lithocholic acid, deoxycholic acid (DCA) and allocholic acid (ACA). Plays a essential role in BA homeostasis through the regulation of genes involved in BA synthesis, conjugation and enterohepatic circulation. Also regulates lipid and glucose homeostasis and is involved innate immune response (PubMed:10334992, PubMed:10334993, PubMed:21383957, PubMed:22820415).

Molecular Function

bile acid binding

bile acid receptor activity

chenodeoxycholic acid binding

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription factor activity

DNA-binding transcription factor activity, RNA polymerase I

Subcellular Location

Nucleus

Expression

Liver and hepatocyte-related cells express mainly FXRalpha1-type isoforms with isoform 3 and isoform 4 in approximately equal proportions. In intestine and kidney mainly FXRalpha2-type isoforms are expressed with isoform 1 and isoform 2 in approximately equal proportions. Expressed in pancreatic beta cells and macrophages.

Structure

Zinc-finger

Alternative Nomenclature

BAR antibody

Bile acid receptor antibody

Farnesoid X activated receptor antibody

Farnesoid X receptor antibody

Farnesol receptor HRR 1 antibody

FXR antibody

HRR 1 antibody

NR1H4 antibody

Nuclear receptor subfamily 1 group H member 4 antibody

Retinoid X receptor interacting protein 14 antibodyRIP 14 antibodyRXR interacting protein 14 antibody

Protein information supplied by UniProt.


Accessories

Product Note Status Price
Bile Acid Receptor NR1H4 Antibody Bile Acid Receptor NR1H4 Antibody
NR1H4-101AP $285.00 *
Bile Acid Receptor NR1H4 Positive Control Bile Acid Receptor NR1H4 Positive Control
PC-NR1H4 $200.00 *
Bile Acid Receptor NR1H4 Blocking Peptide Bile Acid Receptor NR1H4 Blocking Peptide
P-NR1H4 $155.00 *
Bile Acid Receptor NR1H4 Antibody FITC Bile Acid Receptor NR1H4 Antibody FITC
NR1H4-FITC $375.00 *
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