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General Information
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Product
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CCR4 Antibody Antigenic Blocking Peptide
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Description
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Antigenic Blocking Peptide C-C chemokine receptor type 4 Antibody
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Verified Applications
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Immmunodepletion, Competition Assay
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Peptide Description
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Synthetic peptide
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Accession #
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NCBI: NP_005499
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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P51679
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Overview
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Receptor for C-C type chemokines CCL17/TARC and CCL22/MDC. Functions as chemoattractant homing receptor on circulating memory lymphocytes and as coreceptor for some primary HIV-2 isolates. Can also mediate hippocampal-neuron survival.
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Molecular Function
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GPCR, Receptor, Transducer.
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Subcellular Location
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Cell membrane; Multi-pass membrane protein
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Expression
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Thymus, peripheral blood leukocytes including T-cells, CD4+ cells, basophils and in platelets. Expressed less in spleen and in monocytes. Also found in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expresseding cutaneous lymphocyte antigen. Expressed in brain and microvascular and coronary artery endothelial cells.
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Structure
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Belongs to G-protein coupled receptor 1 family. Interacts with CREB3.
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Alternative Nomenclature
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CD194 antibody
ChemR13 antibody
CKR4 antibody
CMKBR 4 antibody
HGCN 14099 antibody
K5 5 antibody
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CCR4 Antibody
CCR4 Antibody FITC
CCR4 Antibody BIOTIN
CCR4 Positive Control
