DYRK1 Blocking Peptide

General Information

Product

DYRK1 Peptide

Description

Antigenic Blocking Peptide Dual specificity tyrosine-phosphorylation-regulated kinase 1A Antibody

Verified Applications

Immunodepletion, Immunocompetition

Peptide Description

Synthetic peptide taken within amino acid region 300-350 on human Dual specificity tyrosine-phosphorylation-regulated kinase 1A.

Physical Properties

Quantity

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Storage

-20⁰C for long term storage

Application Protocol

Competition/Depletion assay

Refer to competition assay protocol

Protein

Uniprot #

Q13627

Overview

May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1, SRSF6 and SIRT1. Exhibits a sugstrate preference for proline at position P+1 and arginine at position P-3

Molecular Function

Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

Subcellular Location

Nucleus speckle

Expression

Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.

Structure

The polyhistidine repeats act as targeting signals to nuclear speckles.

Alternative Nomenclature

Dual specificity tyrosine phosphorylation regulated kinase
Dual specificity YAK1-related kinase
DYRK
DYRK1 
DYRKA
hMNB
HP86
Minibrain, Drosophila, homolog of
MNB
MNB protein kinase
Mnb protein kinase homolog hp86
MNB protein kinase, Serine/threonine-specific
MNB/DYRK protein kinase
MNBH
MRD7 
Protein kinase minibrain homolog
Serine/threonine kinase MNB