DYRK1 Positive Control

General Information

Product

DYRK1 Positive Control

Description

Western Blot Positive Control Dual specificity tyrosine-phosphorylation-regulated kinase 1A Antibody

Verified Applications

WB

Immunogen

Purified protein

Physical Properties

Quantity

5 Applications

Volume

Inquire

Form

Western Blot Positive Control

Purification Method

Immobilized antigen affinity chromatography

Storage

-20⁰C for long term storage

Application Protocol

Western Blot

1:500

Protein

Uniprot #

Q13627

Overview

May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1, SRSF6 and SIRT1. Exhibits a sugstrate preference for proline at position P+1 and arginine at position P-3

Molecular Function

Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

Subcellular Location

Nucleus speckle

Expression

Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.

Structure

The polyhistidine repeats act as targeting signals to nuclear speckles.

Alternative Nomenclature

Dual specificity tyrosine phosphorylation regulated kinase
Dual specificity YAK1-related kinase
DYRK
DYRK1 
DYRKA
hMNB
HP86
Minibrain, Drosophila, homolog of
MNB
MNB protein kinase
Mnb protein kinase homolog hp86
MNB protein kinase, Serine/threonine-specific
MNB/DYRK protein kinase
MNBH
MRD7 
Protein kinase minibrain homolog
Serine/threonine kinase MNB