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General Information
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Product
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ErbB 2 Peptide
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Description
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Antigenic Blocking Peptide Receptor tyrosine-protein kinase erB-2 isoform b
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Verified Applications
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Immunodepletion, Immunocompetition
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Peptide Description
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Synthetic peptide taken within amino acid region 130-180 receptor tyrosine-protein kinase erbB-2 protein.
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Accession #
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NCBI: NP_001005862.1
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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P04626
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Overview
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Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs).
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Molecular Function
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Activator, Kinase, Receptor, Transferase, Tyrosine-protein kinase
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Subcellular Location
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Isoform 1: Cell membrane; Single-pass type I membrane protein, Cytoplasm>perinuclear region, Nucleus. Isoform 2: Cytoplasm, Nucleus. Isoform 3: Cytoplasm, Nucleus.
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Expression
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Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.
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Structure
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Homodimer. Heterodimer with EGFR, ERBB3 and ERBB4. Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196. Interacts with PRKCABP and PLXNB1. Interacts (when phosphorylated on Tyr-1248) with MEMO1. Interacts with MUC1; the interaction is enhanced by hereguline (HRG).
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Alternative Nomenclature
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Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody
c erb B2 antibody
CD340 antibody
cneu antibody
Erb B2 antibody
Erythroblastosis Virus antibody
HER 2 antibody
Herstatin antibody
Metastatic lymph node gene 19 protein antibody
MLN 19 antibody
NEU proto oncogene antibody
Neuro Glioblastoma Derived Oncogene Homolog antibody
NGL antibody
p185 ErbB2 antibody
Proto-oncogene Neu antibody
Receptor Protein Tyrosine Kinase ErbB2 Precursor antibody
TKR1 antibody
verbb2 antibody
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ErbB 2 Antibody
ErbB 2 Antibody FITC
ErbB 2 Antibody BIOTIN
ErbB 2 Positive Control
