FFAR3 Antibody FITC

General Information

Product

FFAR3 Antibody FITC-Conjugated

Description

FITC-Conjugated Free fatty acid receptor A3 Antibody

Verified Applications

ELISA, IP WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 270-320  on human FFAR3 protein.

Accession #

NCBI:  NP_005295.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.58-0.59 µg/µl in antibody stabilization buffer

Form

FITC-Conjugated

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

O14843

Overview

G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation (PubMed:12711604). 

Molecular Function

G-protein coupled receptor activity; Lipid binding

Subcellular Location

Cell Membrane; Multi-Pass Membrane Protein

Expression

Highest level in adipose tissue, and lower expression across all tissues tested. Expressed in sympathetic ganglia.

Structure

Belongs to the G-protein coupled receptor 1 family.

Alternative Nomenclature

FFA3R antibody

Free fatty acid receptor 3 antibody

G protein coupled receptor 41 antibody

GPCR41 antibody

GPR41 antibody

gpr42 antibody