GABA B Receptor 2 Blocking Peptide

General Information

Product

GABA B Receptor 2 Peptide

Description

Antigenic Blocking Peptide Gamma-aminobutyric acid receptor subunit beta-2 N-epitope

Verified Applications

Immunodepletion, Immunocompetition

Peptide Description

Synthetic peptide taken within amino acid region 1-50 on human gamma-aminobutyric acid A receptor beta 2 protein.

Accession #

GenBank: ACY69094.1

Physical Properties

Quantity

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

Competition/Depletion assay

Refer to competition assay protocol

Protein

Uniprot #

P47870

Overview

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.

Molecular Function

Chloride channel activity; GABA-A receptor activity; Inhibitory extracellular ligand-gated ion channel activity

Subcellular Location

Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein

Expression

Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression.

Structure

Binds UBQLN1. Interacts with KCTD8, KCTD12 and KCTD16; this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, althoughto different extents. Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains.

Alternative Nomenclature

GABA-B-R2 antibody

Gamma aminobutyric acid (GABA) B receptor 2 antibody

Gb1 antibody

GPRC3A antibody

Seven transmembrane helix receptor antibody