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General Information
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Product
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HIPK3 Peptide
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Description
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Antigenic Blocking Peptide Homeodomain-interacting protein kinase 3 Antibody
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Verified Applications
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Immunodepletion, Immunocompetition
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Peptide Description
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Synthetic peptide taken within amino aci region 860-910 on human Homeodomain-interacting protein kinase 3 protein.
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Purification Method
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Immobilized antigen affinity chromatography
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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Q9H422
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Overview
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Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).
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Molecular Function
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ATP binding
protein kinase activity
protein serine/threonine kinase activity
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Subcellular Location
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Nucleus, cytoplasm
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Expression
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Overexpressed in multidrug resistant cells. Highly expressed in heart and skeletal muscle, and at lower levels in placenta, pancreas, brain, spleen, prostate, thymus, testis, small intestine, colon and leukocytes. Not found in liver and lung.
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Structure
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Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.
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Alternative Nomenclature
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Androgen receptor interacting nuclear protein kinase antibody
ANPK antibody
DYRK6 antibody
Fas-interacting serine/threonine-protein kinase antibody
FIST antibody
FIST3 antibody
Hipk3 antibody
homeodomain interacting protein kinase 3 antibody
Homolog of protein kinase YAK1 antibody
PKY antibody
RP24 297H17.5 antibody
YAK1 antibody
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HIPK3 Antibody
HIPK3 Antibody BIOTIN
HIPK3 Antibody FITC
HIPK3 Positive Control
