KDM4C / GASC1 / JMJD2C Positive Control

Product no.: PC-JMJ3C
$200.00


General Information

 

 

Product

 

KDM4C / GASC1 / JMJD2C Positive Control

Description

Western Blot Positive Control JmjC domain-containing histone demethylation protein 3C

Verified Applications

WB

Immunogen

Purfied protein.


Physical Properties

 

Quantity

 

5 Applications

Volume

Inquire

Form

Western Blot Positive Control

Storage

-20C for long term storage


Application Protocol

Western Blot

1:2,500-1:5,000


Protein

 

Uniprot #

 

Q9H3R0

Overview

Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.

Molecular Function

androgen receptor binding

chromatin binding

enzyme binding

histone demethylase activity

histone demethylase activity (H3-K36 specific)

histone demethylase activity (H3-K9 specific)

zinc ion binding

Subcellular Location

Nucleus

Expression

Overexpressed in several esophageal squamous cell carcinomas (ESCs).

Structure

The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails.

Alternative Nomenclature

bA146B14.1 antibody

GASC 1 protein antibody

Gene amplified in squamous cell carcinoma 1 protein antibody

JHDM3C antibody

JMJD2C antibody

Jumonji domain containing 2C antibody

Kdm4c antibody

Lysine demethylase 4C antibody

TDRD14C antibody

Tudor domain containing 14C antibody

Protein information supplied by UniProt.


Accessories

Product Note Status Price
KDM4C / GASC1 / JMJD2C Antibody FITC KDM4C / GASC1 / JMJD2C Antibody FITC
JMJ3C-FITC $375.00 *
KDM4C / GASC1 / JMJD2C Blocking Peptide KDM4C / GASC1 / JMJD2C Blocking Peptide
P-JMJ3C $155.00 *
KDM4C / GASC1 / JMJD2C Antibody BIOTIN KDM4C / GASC1 / JMJD2C Antibody BIOTIN
JMJ3C-BIOTIN $375.00 *
KDM4C / GASC1 / JMJD2C Antibody KDM4C / GASC1 / JMJD2C Antibody
JMJ3C-101AP $285.00 *
Display accessory details