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General Information
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Product
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MAPK7 Peptide
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Description
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Antigenic Blocking Peptide Mitogen-activated protein kinase 7 Antibody
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Verified Applications
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Immunodepletion, Immunocompetition
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Peptide Description
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Synthetic peptide taken within amino acid region 700-750 on human Mitogen-activated protein kinase 7.
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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1:500
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Protein
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Uniprot #
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Q13164
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Overview
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Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.
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Molecular Function
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Kinase, Serine/threonine-protein kinase, Transferase
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Subcellular Location
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Cytoplasm, Nucleus, PML body
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Expression
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Expressed in many adult tissues. Abundant in heart, placenta, lung, kidney and skeletal muscle. Not detectable in liver.
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Structure
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The second proline-rich region may interact with actin targeting the kinase to a specific location in the cell.
The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
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Alternative Nomenclature
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Big MAP kinase 1 antibody
BMK 1 kinase antibody
ERK 5 antibody
Extracellular signal regulated kinase 5 antibody
MAP kinase 7 antibody
Mitogen-activated protein kinase 7 antibody
PRKM 7 antibody
PROTEIN KINASE, MITOGEN-ACTIVATED, 7 antibody
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MAPK7 Antibody
MAPK7 Antibody BIOTIN
MAPK7 Antibody FITC
MAPK7 Positive Control
