MERTK Blocking Peptide

Product no.: P-MKT100

$155.00

Description
Publications

General Information
Product	MERTK Peptide
Description	Antigenic Blocking Peptide Human cellular proto-oncogene (c-mer) Antibody C-epitope
Verified Applications	Immunocompetition, Immunodepletion
Peptide Description	Synthetic peptide taken within amino acid region 900-994 on MerTK protein.
Accession #	NCBI: NP_075232
Physical Properties
Quantity	250 µg
Volume	100 µl
Form	Antigenic Blocking Peptide
Determinant	C-epitope
Storage	-20⁰C for long term storage
Application Protocol
Competition/Depletion assay	Refer to competition assay protocol
Protein
Uniprot #	P57097
Overview	Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3 (By similarity).
Molecular Function	Kinase, Receptor, Transferase, Tyrosine-protein kinase
Subcellular Location	Membrane; Single-pass type I membrane protein
Expression	Is expressed in many neoplastic B- and T-cells. Is expressed highly in testis, ovary, prostate, lung and kidney and is expressed at low levels in the spleen, small intestine, colon and liver.
Structure	Interacts with TNK2 upon activation. Interacts with extracellular ligands LGALS3, TUB, TULP1, and GAS6.
Alternative Nomenclature	c MER antibody c mer proto oncogene tyrosine kinase antibody Eyk antibody MER antibody MER receptor tyrosine kinase antibody MERK antibody MERPEN antibody Mertk antibody MERTK c-mer proto-oncogene tyrosine kinase antibody MGC133349 antibody nmf12 antibody Nyk antibody Proto oncogene tyrosine protein kinase MER antibody Proto-oncogene c-Mer antibody Receptor tyrosine kinase MerTK antibody RP38 antibody STK kinase antibody Tyrosine-protein kinase Mer antibody

Protein information supplied by UniProt

Fabgennix MerTK Antibody has been used in 17 Publications
Ginisty, Aurélie, et al. "Evidence for a Subventricular Zone Neural Stem Cell Phagocytic Activity Stimulated by the Vitamin K‐Dependent Factor Protein S." STEM CELLS 33.2 (2015): 515-525. PMID25308179	Western Blot; Rat
Farkas, Michael H., et al. "Mutations in Pre-mRNA Processing Factors 3, 8, and 31 Cause Dysfunction of the Retinal Pigment Epithelium." The American journal of pathology 184.10 (2014): 2641-2652. PMID25111227	Immunofluorescence; Mouse
Teplova, Irina, et al. "ATG proteins mediate efferocytosis and suppress inflammation in mammary involution." Autophagy 9.4 (2013): 459-475.PMID23380905	Immunohistochemistry; Mouse
Choi, Ji-Yeon, et al. "Upregulation of Mer receptor tyrosine kinase signaling attenuated lipopolysaccharide-induced lung inflammation." Journal of Pharmacology and Experimental Therapeutics 344.2 (2013): 447-458. PMID23197771	Western Blot; Mouse
Suleiman, Lutfi, Claude Négrier, and Habib Boukerche. "Protein S: A multifunctional anticoagulant vitamin K-dependent protein at the crossroads of coagulation, inflammation, angiogenesis, and cancer." Critical Reviews in oncology/hematology 88.3 (2013): 637-654. PMID23065156	Western Blot; Mouse
Fraineau, Sylvain, et al. "The vitamin K–dependent anticoagulant factor, protein S, inhibits multiple VEGF-A–induced angiogenesis events in a Mer-and SHP2-dependent manner." Blood 120.25 (2012): 5073-5083. PMID23065156	Western Blot; Human, Mouse
Lee, Ye-Ji, et al. "Inhibiting Mer receptor tyrosine kinase suppresses STAT1, SOCS1/3, and NF-κB activation and enhances inflammatory responses in lipopolysaccharide-induced acute lung injury." Journal of leukocyte biology 91.6 (2012): 921-932. PMID22427680	Western Blot; Mouse
Caberoy, Nora B., Gabriela Alvarado, and Wei Li. “Tubby Regulates Microglial Phagocytosis through MerTK.” Journal of neuroimmunology252.1-2 (2012): 40–48. PMC3466361	Immunoprecipitation; Mouse
Caberoy, Nora B. et al. “Galectin-3 Is a New MerTK-Specific Eat-Me Signal.”Journal of cellular physiology 227.2 (2012): 401–407. PMC3225605	Immunoprecipitation; Mouse
Qin, Suofu, and Gerard A. Rodrigues. "Roles of αvβ5, FAK and MerTK in oxidative stress inhibition of RPE cell phagocytosis." Experimental eye research 94.1 (2012): 63-70. PMID22138557	Western Blot; Human
Brown, Jessica E. et al. “Cross-Phosphorylation, Signaling and ProlifeRative Functions of the Tyro3 and Axl Receptors in Rat2 Cells.” Ed. Michael Polymenis. PLoS ONE 7.5 (2012): e36800. PMC3351477	Western Blot; Mouse
Lee, Ye-Ji, et al. "Inhibiting Mer receptor tyrosine kinase suppresses STAT1, SOCS1/3, and NF-κB activation and enhances inflammatory responses in lipopolysaccharide-induced acute lung injury." Journal of leukocyte biology 91.6 (2012): 921-932. PMID22427680	Western Blot; Mouse
Caberoy, Nora B., Yixiong Zhou, and Wei Li. "Tubby and tubby‐like protein 1 are new MerTK ligands for phagocytosis." The EMBO journal 29.23 (2010): 3898-3910. PMID20978472	Immunohistochemistry, Western Blot; Human, Mouse
Tibrewal, Nitu, et al. "Autophosphorylation docking site Tyr-867 in Mer receptor tyrosine kinase allows for dissociation of multiple signaling pathways for phagocytosis of apoptotic cells and down-modulation of lipopolysaccharide-inducible NF-κB transcriptional activation." Journal of Biological Chemistry 283.6 (2008): 3618-3627. PMID18039660	Immunoprecipitation, Western Blot; Human
Sather, Susan, et al. "A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation." Blood 109.3 (2007): 1026-1033. PMID17047157	Flow Cytometry; Human, Mouse
Wu, Yi, et al. "A role for Mer tyrosine kinase in αvβ5 integrin-mediated phagocytosis of apoptotic cells." Journal of cell science 118.3 (2005): 539-553. PMID15673687	Flow Cytometry; Mouse
Mahajan, Nupam P., and H. Shelton Earp. "An SH2 Domain-dependent, Phosphotyrosine-independent Interaction between Vav1 and the Mer Receptor Tyrosine Kinase A MECHANISM FOR LOCALIZING GUANINE NUCLEOTIDE-EXCHANGE FACTOR ACTION." Journal of Biological Chemistry 278.43 (2003): 42596-42603. PMID12920122	Immunoprecipitation, Western Blot; Mouse