PDE4D5 Blocking Peptide

Product no.: P-PD4D5

$155.00

Description
Publications

General Information
Product	PDE4D5 Peptide
Description	Antigenic Blocking Peptide cAMP-specific phosphodiesterase PDE4D5
Verified Applications	Immunodepletion, Immunocompetition
Peptide Description	A 20 amino acid synthetic peptide taken from the N-terminus corresopnding to the PDE4D5 variant.
Accession #	GenBank: AAC00069.1
Physical Properties
Quantity	250 µg
Volume	100 µl
Form	Antigenic Blocking Peptide
Storage	-20⁰C for long term storage
Application Protocol
Competition/Depletion assay	Refer to competition assay protocol
Protein
Uniprot #	Q08499
Overview	Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Molecular Function	Hydrolase, 3',5'-cyclic-AMP phosphodiesterase activity, cAMP binding
Subcellular Location	Apical cell membrane, Cytoplasm, Membrane
Expression	Expressed in colonic epithelial cells (at protein level). Widespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle.
Structure	Homodimer for the long isoforms. Isoforms with truncated N-termini are monomeric. Isoform 3 is part of a ternary complex containing PRKAR2A, PRKAR2B and AKAP9. Interacts with PDE4DIP. Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphotase 1 (PP1) (By similarity). Isoform 5, isoform N3 and isoform 12 bind GNB2L1 via their unique N-terminus. Binds ARRB2. Interacts (via N-terminal region) with SHANK2 (via proline-rich region); the interaction is increased in a PKA-dependent manner.
Alternative Nomenclature	cAMP-specific 3'5'-cyclic phosphodiesterase 4D antibody DPDE3 antibody dunce-like phosphodiesterase E3 antibody hPDE4D5 antibody PDE4D antibody PDE4DN2 antibody Phosphodiesterase 4D antibody Phosphodiesterase 4D cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E3) antibody Phosphodiesterase 4D cAMP-specific antibody STRK1 antibody

Protein information supplied by UniProt

Fabgennix PDE4D5 Antibody has been used in 7 Publications

Zamarbide, Marta, et al. "Male-Specific cAMP Signaling in the Hippocampus Controls Spatial Memory Deficits in a Mouse Model of Autism and Intellectual Disability." Biological psychiatry 85.9 (2019). PMID30732858

Western Blot; Mouse

Wang, Zhen-Zhen, et al. "Phosphodiesterase-4D Knock-down in the Prefrontal Cortex Alleviates Chronic Unpredictable Stress-Induced Depressive-Like Behaviors and Memory Deficits in Mice." Scientific Reports 5 (2015). PMID26161529

Western Blot; Mouse

Mahavadi, Sunila, et al. "Cytokine-induced iNOS and ERK1/2 inhibit adenylyl cyclase type 5/6 activity and stimulate phosphodiesterase 4D5 activity in intestinal longitudinal smooth muscle." American Journal of Physiology-Cell Physiology 307.4 (2014): C402-C411. PMID24944202

Western Blot; Mouse

Li, Yun-Feng et al. “Phosphodiesterase-4D Knockout and RNAi-Mediated Knockdown Enhance Memory and Increase Hippocampal Neurogenesis via Increased cAMP Signaling.” The Journal of neuroscience : the official journal of the Society for Neuroscience 31.1 (2011): 172–183. PMC3079568

Immunohistochemistry, Western Blot; Mouse

Nino, Gustavo et al. “Mechanism Regulating Proasthmatic Effects of Prolonged Homologous Β2-Adrenergic Receptor Desensitization in Airway Smooth Muscle.” American Journal of Physiology - Lung Cellular and Molecular Physiology 297.4 (2009): L746–L757. PMC2770790

Western Blot; Rabbit

Murthy, Karnam S., and Wimolpak Sriwai. "Stimulatory phosphorylation of cAMP-specific PDE4D5 by contractile agonists is mediated by PKC-dependent inactivation of protein phosphatase 2A." American Journal of Physiology-Gastrointestinal and Liver Physiology 294.1 (2008): G327-G335. PMID18006600

Immunoprecipitation, Western Blot; Human

Hajjhussein, Hassan et al. “Changes in NMDA Receptor-Induced Cyclic Nucleotide Synthesis Regulate the Age-Dependent Increase in PDE4A Expression in Primary Cortical Cultures.” Brain research 1149 (2007): 58–68. PMC2720317

Immunoprecipitation, Western Blot; Human

Publishing research using PD4D5-451AP? Please let us know, we can cite the reference in this datasheet.