General Information
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Product
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PDE4D7 Antibody BIOTIN-Conjugated
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Description
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BIOTIN-Conjugated cAMP-specific phosphodiesterase PDE4D7 Antibody
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Verified Applications
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ELISA, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Chicken, Mouse, Rat
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Immunogen
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Synthetic peptide corresponding to unique amino acid sequence on PDE4D7 variant.
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Specificity |
This antibody does not cross react with other PDE4D variants including PDE4D1, PDE4D2, PDE4D3, PDE4D4, PDE4D5. It also does not cross react with other PDE family members including PDE4A, PDE4B or PDE4C. |
Accession #
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GenBank: AF536978.1
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.2 µg/µl in antibody stabilization buffer
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Form
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BIOTIN-Conjugated
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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DB
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1:10,000
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ELISA
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1:10,000
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Immunoprecipitation
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1:150
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Western Blot
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1:500
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Protein
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Uniprot #
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Q01063
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Overview
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Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
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Molecular Function
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Hydrolase, 3',5'-cyclic-nucleotide phosphodiesterase activity, ATPase binding
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Subcellular Location
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Cytoplasm. Membrane. Cytoplasm › cytoskeleton. Cytoplasm › cytoskeleton › microtubule organizing center › centrosome. Apical cell membrane
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Expression
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Expressed in brain (at protein level). Isoform 7 is detected in heart, brain, lung, kidney and testis.
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Structure
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Homodimer for the long isoforms. Isoforms with truncated N-termini are monomeric. Binds ARRB2. Interacts with PDE4DIP (By similarity). Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1). Interacts (via N-terminal region) with SHANK2 (via proline-rich region); the interaction is increased in a PKA-dependent manner.
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Alternative Nomenclature
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DPDE3 antibody
HSPDE4D antibody
PDE43 antibody
PDE4D antibody
Phosphodiesterase 4D antibody
Phosphodiesterase 4D cAMP-specific antibody
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