Phospho-JAK2 Positive Control

General Information

Product

Phospho-JAK2 Positive Control

Description

Western Blot Positive Control Phosphorylated Tyrosine-protein kinase JAK2 Antibody

Verified Applications

WB

Form

Purified Protein

Physical Properties

Quantity

5 Applications

Volume

Inquire

Form

Western Blot Positive Control

Storage

-20⁰C for long term storage

Application Protocol

Western Blot

1:500

Protein

Uniprot #

O60674

Overview

Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins (PubMed:7615558). Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins (PubMed:9618263). Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor.

Molecular Function

Adaptive immunity, Immunity, Innate immunity

Subcellular Location

Endomembrane system; Peripheral membrane protein; Cytoplasm; Nucleus

Expression

Ubiquitously expressed throughout most tissues.

Structure

Possesses 2 protein kinase domains. The second one probably contains the catalytic domain, while the presence of slight differences suggest a different role for protein kinase 1.

Alternative Nomenclature

JAK 2 

Janus Activating Kinase 2 

Janus kinase 2 (a protein tyrosine kinase) 

Janus kinase 2 

JTK 10 

THCYT3 

Tyrosine protein kinase JAK2