Phospho-PDE7A Blocking Peptide

General Information

Product

Phospho-PDE7A Peptide

Description

Antigenic Blocking Peptide High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A

Verified Applications

Immunodepletion, Immunocompetition

Peptide Description

Phosphorylated Synthetic cyclic peptide common to all PDE7A variants

Physical Properties

Quantity

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Storage

-20⁰C for long term storage

Application Protocol

Competition/Depletion assay

Refer to competition assay protocol

Protein

Uniprot #

P70453

Overview

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.

Molecular Function

Hydrolase, 3', 5' -cyclic-AMP phosphodiesterase activity

Subcellular Location

Cytoplasm

Expression

PDE7A1 is found at high levels in skeletal muscle and at low levels in a variety of tissues including brain and heart. It is expressed as well in two T-cell lines. PDE7A2 is found abundantly in skeletal muscle and at low levels in heart. Developmentally regulated. PDE7A1 and PDE7A2 are found in several fetal tissues, expression is reduced throughout development. It persists strongly only in adult skeletal muscle.

Structure

Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.

Alternative Nomenclature

HCP 1 antibody

P2A antibody

PDE 7 antibody

PDE 7A antibody

PDE1/PDE2 yeast human complement of antibody

PDE7 antibody

PDE71 antibody

Phosphodiesterase 7A antibody

Phosphodiesterase isozyme 7 antibody

Rolipram insensitive phosphodiesterase type 7 antibody

TM22 antibody