Prominin 1 Antibody

Product no.: PROM-101AP

$285.00

Description

General Information
Product	Prominin 1 Antibody
Verified Applications	ELISA, IHC, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide taken within amino acid regions 700-730 on CD133 protein
Accession #	NCBI: XP_006714037.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.50-0.95 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:2,000
ELISA	1:2,000
Immunohistochemistry	1:100
Western Blot	1:500-1:1,000
Protein
Uniprot #	UPI0003EAF562
Overview	May play a role in cell differentiation, proliferation and apoptosis (PubMed:24556617). Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner (PubMed:20818439).
Molecular Function	Actinin binding; Cadherin binding
Subcellular Location	Apical cell membrane; Multi-pass membrane protein; microvillus membrane; cilium; photoreceptor outer segment.
Expression	Isoform 1 is selectively expressed on CD34 hematopoietic stem and progenitor cells in adult and fetal bone marrow, fetal liver, cord blood and adult peripheral blood. Isoform 1 is not detected on other blood cells. Isoform 1 is also expressed in a number of non-lymphoid tissues including retina, pancreas, placenta, kidney, liver, lung, brain and heart. Found in saliva within small membrane particles. Isoform 2 is predominantly expressed in fetal liver, low in bone marrow, and barely detectable in peripheral blood. Isoform 2 is expressed on hematopoietic stem cells and in epidermal basal cells (at protein level). Expressed in adult retina by rod and cone photoreceptor cells (at protein level).
Structure	Interacts with CDHR1 and with actin filaments. Interacts with NAT8 and NAT8B.
Alternative Nomenclature	AC133 antibody CD133 antibody CORD12 antibody Hematopoietic stem cell antigen antibody MCDR2 antibody MSTP061 antibody RP41 antibody STGD4 antibody

Protein information supplied by UniProt