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General Information
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Product
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Prominin 1 Peptide
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Verified Applications
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Immunodepletion, Immunocompetition
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Peptide Description
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Synthetic peptide taken within amino acid regions 700-730 on CD133 protein
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Accession #
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NCBI: XP_006714037.1
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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UPI0003EAF562
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Overview
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May play a role in cell differentiation, proliferation and apoptosis (PubMed:24556617). Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner (PubMed:20818439).
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Molecular Function
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Actinin binding; Cadherin binding
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Subcellular Location
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Apical cell membrane; Multi-pass membrane protein; microvillus membrane; cilium; photoreceptor outer segment; Endoplasmic reticulum-Golgi intermediate compartment
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Expression
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Isoform 1 is selectively expressed on CD34 hematopoietic stem and progenitor cells in adult and fetal bone marrow, fetal liver, cord blood and adult peripheral blood. Isoform 1 is not detected on other blood cells. Isoform 1 is also expressed in a number of non-lymphoid tissues including retina, pancreas, placenta, kidney, liver, lung, brain and heart. Found in saliva within small membrane particles. Isoform 2 is predominantly expressed in fetal liver, low in bone marrow, and barely detectable in peripheral blood. Isoform 2 is expressed on hematopoietic stem cells and in epidermal basal cells (at protein level). Expressed in adult retina by rod and cone photoreceptor cells (at protein level).
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Structure
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Interacts with CDHR1 and with actin filaments. Interacts with NAT8 and NAT8B.
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Alternative Nomenclature
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AC133 antibody
CD133 antibody
CORD12 antibody
Hematopoietic stem cell antigen antibody
MCDR2 antibody
MSTP061 antibody
RP41 antibody
STGD4 antibody
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Prominin 1 Antibody
Prominin 1 Antibody FITC
Prominin 1 Antibody BIOTIN
Prominin 1 Positive Control
