Prostaglandin E Receptor EP2 Antibody BIOTIN

General Information

Product

Prostaglandin E2 receptor EP3 subtype Antibody BIOTIN-Conjugated

Description

BIOTIN-Conjugated Prostaglandin E2 Receptor subtype isoform 7 Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse

Immunogen

Synthetic peptide taken within amino acid region 300-350 on human Prostaglandin E2 receptor EP3 subtype.

Accession #

NCBI:  NP_942010.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-0.6 µg/µl in antibody stabilization buffer

Form

BIOTIN-Conjugated

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:250

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunoprecipitation

1:250

Western Blot

1:500

Protein

Uniprot #

P43115

Overview

Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems (By similarity).

Molecular Function

Prostaglandin E receptor activity, G-protein coupled receptor

Subcellular Location

Cell membrane; Multi-pass membrane

Expression

Expressed in small intestine, heart, pancreas, gastric fundic mucosa, mammary artery and pulmonary vessels.

Structure

Belongs to the G-protein coupled receptor 1 family.

Alternative Nomenclature

EP 2 antibody

Human prostaglandin E2 receptor antibody

PGE2 receptor EP2 subtype antibody

Prostaglandin E receptor 2 EP2 subtype antibody

PTGER2 antibody