RASGRF2 Positive Control

General Information

Product

RASGRF2 Positive Control

Description

Western Blot Positive Control Ras-specific guanine nucleotide-releasing factor 2

Verified Applications

WB

Immunogen

Purified Protein

Physical Properties

Quantity

5 Applications

Volume

Inquire

Form

Western Blot Positive Control

Storage

-20⁰C for long term storage

Application Protocol

Western Blot

1:500

Protein

Uniprot #

O14827

Overview

Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP.  Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation.

Molecular Function

Guanine-nucleotide releasing factor, Rho guayl-nucleotide exchange factor activity

Subcellular Location

Cytoplasm, Cell membrane; Peripheral membrane protein, Endoplasmic reticulum membrane; Peripheral membrane protein

Expression

Widely expressed with higher expression in the brain, followed by heart, lung, pancreas and kidney.  Detected in placenta.  Expressed in brain and lung.

Structure

Homooligomer and heterooligomer with RASGRF1.  Interacts with Ras and RAC1.  Interacts in a calcium-dependent manner with calmodulin.

Alternative Nomenclature

GRF2 antibody

Ras guanine nucleotide exchange factor 2 antibody

Ras-GRF2 antibody