Timeless Antibody BIOTIN

General Information

Product

Timeless Antibody BIOTIN

Description

BIOTIN-Conjugated Protein timeless homolog isoform 2 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic peptide:

SGTPRVHRKKRFQIEDEDD

coresponding to amino acids 1178-1197 on Mouse Timeless protein.

Accession #

NCBI:  NP_035719.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.98-1.26 µg/µl in antibody stabilization buffer

Form

BIOTIN-Conjugated

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9R1X4

Overview

Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication and in the regulation of the circadian clock. Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock.

Molecular Function

Developmental protein, protein heterodimerization activity, protein homodimerization activity

Subcellular Location

Nucleus

Expression

Predominantly and robustly expressed in proliferative organs (spleen, thymus, intestine and testis) compared to those more differentiated such as kidney and liver (at protein level). Expressed in all tissues examined including brain, heart, lung, liver, skeletal muscle, kidney, placenta, pancreas, spleen, thymus and testis.

Structure

Homodimer or homomultimer. 

Alternative Nomenclature

Protein timeless homolog antibody

TIM antibody

timeless circadian clock 1 antibody

TIMELESS1 antibody

Tof1 homolog antibody