Topoisomerase II alpha Antibody

Product no.: TOPO2A-201AP

$285.00

Description

General Information
Product	Topoisomerase II alpha Antibody
Description	Affinity Purified DNA topoisomerase (ATP-hydrolysing) Antibody
Verified Applications	ELISA, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide taken within amino acid region 1220-1270 on human DNA topoisomerase (ATP-hydrolysing) protein.
Accession #	GenBank: CAA09762.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.54-0.57 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:10,000
ELISA	1:10,000
Immunoprecipitation	1:200
Western Blot	1:500
Protein
Uniprot #	P11388
Overview	Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes.
Molecular Function	Isomerase, Topoisomerase, ATP binding
Subcellular Location	Cytoplasm, Nucleus
Structure	Homodimer. Interacts with COPS5. Interacts with RECQL5; this stimulates DNA decatenation. Interacts with SETMAR; stimulates the topoisomerase activity.
Alternative Nomenclature	alpha isozyme antibody ATP hydrolyzing DNA topoisomerase II alfa antibody DNA gyrase antibody DNA topoisomerase 2 alpha antibody DNA topoisomerase II 170 kD antibody DNA topoisomerase II alpha isozyme antibody TOP2 antibody TOP2A antibody Topoisomerase DNA II alpha 170kDa antibody TP2A antibody

Protein information supplied by UniProt

Synthetic peptide taken within amino acid region 1220-1270 on human DNA topoisomerase (ATP-hydrolysing) protein.