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General Information
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Product
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c-Fos Peptide
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Description
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Antigenic Blocking Peptide Proto-oncogene c-Fos Antibody
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Verified Applications
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Immunodepletion, Immunocompetition
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Peptide Description
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Synthetic peptide taken within amino acid region 50-100 on human c-fos.
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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P01100
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Overview
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Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.
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Molecular Function
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chromatin binding
DNA-binding transcription activator activity, RNA polymerase II-specific
DNA-binding transcription factor activity
DNA-binding transcription factor activity, RNA polymerase II-specific
protein heterodimerization activity
RNA polymerase
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Subcellular Location
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Nucleus, Cytosol
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Expression
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Expressed at very low levels in quiescent cells. When cells are stimulated to reenter growth, they undergo 2 waves of expression, the first one peaks 7.5 minutes following FBS induction. At this stage, the protein is localized endoplasmic reticulum.
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Structure
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Belongs to the bZIP family. Fos subfamily.
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Alternative Nomenclature
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Activator protein 1 antibody
AP 1 antibody
C FOS antibody
Cellular oncogene c fos antibody
FBJ murine osteosarcoma viral (v fos) oncogene homolog (oncogene FOS) antibody
FBJ Osteosarcoma Virus antibody
FOS antibody
FOS_HUMAN antibody
G0 G1 switch regulatory protein 7 antibody
G0S7 antibody
Oncogene FOS antibody
p55 antibody
proto oncogene c Fos antibody
v fos FBJ murine osteosarcoma viral oncogene homolog antibody
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c-Fos Antibody
c-Fos Antibody BIOTIN
c-Fos Antibody FITC
c-Fos Positive Control
