c-Fos Positive Control

General Information

Product

c-Fos Positive Control

Description

Western Blot Positive Control Proto-oncogene c-Fos

Verified Applications

WB

Physical Properties

Quantity

5 Applications

Volume

Inquire

Concentration

The concentration of the sample is empirically set so that 20 µl per lane in Western and blotted with corresponding affinity purified antibody will give a clean band with a high signal to noise ratio on the gel.

Form

Western Blot Positive Control

Storage

-20⁰C for long term storage

Protein

Uniprot #

P01100

Overview

Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.

Molecular Function

chromatin binding

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription factor activity

DNA-binding transcription factor activity, RNA polymerase II-specific

protein heterodimerization activity

RNA polymerase

Subcellular Location

Nucleus, Cytosol

Expression

Expressed at very low levels in quiescent cells. When cells are stimulated to reenter growth, they undergo 2 waves of expression, the first one peaks 7.5 minutes following FBS induction. At this stage, the protein is localized endoplasmic reticulum.

Structure

Belongs to the bZIP family. Fos subfamily.

Alternative Nomenclature

Activator protein 1 antibody

AP 1 antibody

C FOS antibody

Cellular oncogene c fos antibody

FBJ murine osteosarcoma viral (v fos) oncogene homolog (oncogene FOS) antibody

FBJ Osteosarcoma Virus antibody

FOS antibody

FOS_HUMAN antibody

G0 G1 switch regulatory protein 7 antibody

G0S7 antibody

Oncogene FOS antibody

p55 antibody

proto oncogene c Fos antibody 

v fos FBJ murine osteosarcoma viral oncogene homolog antibody