General Information |
|
Product |
Presenilin 1 Peptide |
Description |
Antigenic Blocking Peptide Presenilin 1 (Alzheimer disease 3) Antibody C-epitope |
Verified Applications |
Immunodepletion, Immunocompetition |
Peptide Description |
Synthetic peptide taken within amino acid region 417-467 on human Presnelin-1 protein. |
Accession # |
GenBank: EAW81096.1 |
|
|
Quantity |
250 µg |
Volume |
100 µl |
Form |
Antigenic Blocking Peptide |
Determinant |
C-epitope |
Storage |
-20⁰C for long term storage |
|
|
Competition/Depletion assay |
|
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|
Uniprot # |
|
Overview |
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis. |
Molecular Function |
Hydrolase, Protease |
Subcellular Location |
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell surface |
Expression |
Expressed in a wide range of tissues including various regions of the brain, liver, spleen and lymph nodes. |
Structure |
Homodimer |
Alternative Nomenclature |
AD3 antibody FAD antibody Homo Sapiens Clone CC44 Senilin 1 antibody Presenilin-1 CTF12 antibody Protein S182 antibody PS 1 antibody PSEN1 antibody S182 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
PSEN-112AP | |||
|
PSEN.112-FITC | |||
|
PSEN.112-BIOTIN | |||
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PC-PSEN | |||
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