General Information

Product

SIRT1 Antibody

Description

Affinity Purified NAD-dependent protein deacetylase sirtuin-1 isoform 1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Chicken, Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid 25-75 on rat Sirtuin 1 protein.

Accession #

NCBI:  NP_062786.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.69-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q923E4

Overview

NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autphagy.

Subcellular Location

Nucleus, PML body, cytoplasm. (Nucleus: Recruited to the nuclear bodies via its interaction with the PML. Colocalized with APEX1 in nucleus. May be found in nucleolus, nuclear euchromatin, heterochromatin and inner membrane. Shuttles between nucleus and cytoplasm).

Expression

Widely expressed. Weakly expressed in liver and skeletal muscle.

Alternative Nomenclature

75SirT1 antibody

HST2, S. cerevisiae, homolog of antibody

NAD dependent deacetylase sirtuin 1 antibody

Regulatory protein SIR2 homolog 1 antibody

SIR2 like protein 1 antibody

SIR2, S.cerevisiae, homolog-like 1 antibody

SIR2ALPHA antibody

SIR2L1 antibody

SirtT1 75 kDa fragment antibody

Sirtuin type 1 antibody

General Information

Product

Survivin Antibody Affinity Purified

Description

Affinity Purified Baculoviral IAP repeat-containing protein 5 isoform 2 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequences on human Survivin protein.

Accession #

NCBI:  NP_001012270.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50-1.50 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O15392

Overview

Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.

Molecular Function

Protease inhibitor, Repressor, Thiol protease inhibitor

Subcellular Location

Cytoplasm, Nucleus, Chromsome, Centromere, Cytoskeleton, Spindle, Kinetochore, Midbody

Expression

Expressed only in fetal kidney and liver, and to lesser extent, lung and brain. Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas. Also expressed in various renal cell carcinoma cell lines.

Structure

Monomer or Homodimer.

Alternative Nomenclature

API4 antibody

Apoptosis Inhibitor 4 antibody

Apoptosis inhibitor survivin antibody

Baculoviral IAP repeat-containing protein 5 antibody

BIRC 5 antibody

EPR 1 antibody

IAP4 antibody

Survivin variant 3 alpha antibody

SVV antibody

TIAP antibody

General Information

Product

CD86 Antibody Affinity Purified

Description

Affinity Purified T-lymphocyte activation antigen CD86 isoform 1 precursor Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region 250-329 on human CD86 protein.

Accession #

NCBI:  NP_787058

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:20,000

ELISA

1:20,000

Western Blot

1:500

Protein

Uniprot #

P42081

Overview

Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.

Molecular Function

Receptor; Adaptive Immunity; Host-virus interaction; Immunity

Subcellular Location

Cell membrane; Single-pass type I membrane protein

Expression

Expressed by activated B-lymphocytes and monocytes.

Structure

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.  Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Alternative Nomenclature

Activation B7 2 antigen antibody

B-lymphocyte activation antigen B7-2 antibody

B7 2 antibody

B70 antibody

BU63 antibody

CD 86 antibody

CD28 antigen ligand 2 2 antibody

CLS1 antibody

CTLA 4 counter receptor B7 2 antibody

Early T-cell costimulatory molecule 1 antibody

ETC-1 antibody

FUN 1 antibody

LAB72 antibody

Ly-58 antibody

MB7-2 antibody

Membrane glycoprotein antibody

MGC34413 antibody

T-lymphocyte activation antigen CD86 antibody

TS/A-2 antibody

General Information

Product

FAM38A Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken between TMD14 and TMD15 on human FAM38A protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q92508

Overview

Pore-forming subunit of a mechanosensitive non-specific cation channel;positive regulation of cell-cell adhesion mediated by integrin

Molecular Function

Ion channel

Subcellular Location

Cell membrane, Endoplasmic reticulum, Membrane

Expression

Expressed in numerous tissues. In normal brain, expressed exclusively in neurons, not in astrocytes;Expressed in erythrocytes

Structure

Homooligomer, most likely homotetramer

Alternative Nomenclature

DHS antibody

Fam38a antibody

Family with sequence similarity 38 member A antibody

KIAA0233 antibody

Membrane protein induced by beta-amyloid treatment antibody

Mib antibody

Piezo-type mechanosensitive ion channel component 1 antibody

Protein FAM38A antibody

Protein FAM38B antibody

Protein PIEZO1 antibody

General Information

Product

GFAP Antibody

Description

Affinity Purified Glial fibrillary acidic protein Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 50-100 on human glial fibrillary acidic protein.

Accession #

PRF:  226236

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

P14136

Overview

GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.

Molecular Function

Structural Constituent of Cytoskeleton; Astrocyte development; Bergmann glial cell differentiation

Subcellular Location

Cytoplasm

Expression

Expressed in cells lacking fibronectin.

Structure

Interacts with SYNM (By similarity). Isoform 3 interacts with PSEN1 (via N-terminus).

Alternative Nomenclature

Astrocyte antibody

FLJ42474 antibody

FLJ45472 antibody

GFAP antibody

Glial Fibrillary Acidic Protein antibody

Intermediate filament protein antibody

General Information

Product

Golgin A1 Antibody

Description

Affinity Purified Golgin subfamily A member 1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 650-700 on mouse Golgin subfamily A member 1 isoform b protein.

Accession #

NCBI:  NP_001277578.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q9CW79

Overview

Probably involved in maintaining Golgi structure. May play a role in acrosome formation and spermatogenesis.

Molecular Function

Protein targeting to Golgi

Subcellular Location

Golgi apparatus > Golgi stack membrane; Peripheral Membrane protein

Expression

Present in the acrosome of spermatids up to the late cap-stage, but not in mature spermatozoa.

Structure

Extended rod-like protein with coiled-coil domains; Contains 1 GRIP domain.

Alternative Nomenclature

Gap junction protein alpha 4 37kD antibody

Golga 1 antibody

Golgi autoantigen golgin subfamily A member 1 antibody

Golgin A1 antibody

Golgin subfamily A member 1 antibody

Golgin-97 antibody

MGC33154 antibody

General Information

Product

Golgin A5 Antibody

Description

Affinity Purified Golgin subfamily A member 5 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 660-710 on human Golgin subfamily A member 5 protein.

Accession #

NCBI:  NP_005104.3

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q8TBA6

Overview

Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.

Molecular Function

Protein homodimerization activity; Rab GTPase binding

Subcellular Location

Golgi apparatus membrane; Single-pass type IV membrane protein

Expression

Ubiquitous. Highly expressed in seminiferous tubules and Leydig cells in testis, and detected at much lower levels in the other tissues tested. Expression is very low or not detectable in spermatozoa.

Structure

Homodimer. Interacts with RAB1A that has been activated by GTP-binding, and possibly also with OCRL1. Interacts with isoform CASP of CUX1.

Alternative Nomenclature

Cell proliferation inducing gene 31 antibody

GOLGA5 antibody

Golgi autoantigen golgin subfamily a 5 antibody

Golgi integral membrane protein 5 antibody

Golgin 84 antibody

Golgin A5 antibody

Golgin subfamily A member 5 antibody

Golgin84 antibody

GOLIM5 antibody

Protein Ret-II antibody

PTC5 antibody

RET fused gene 5 protein antibody

Ret II antibody

RET-fused gene 5 protein antibody

RFG 5 antibody

General Information

Product

Golgin A4 Antibody

Description

Affinity Purified Golgin-245 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Immunogen

Synthetic peptide taken within amino acid region 2025-2075 on human Golgin-245 protein.

Accession #

GenBank: AAC51791.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q13439

Overview

May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1.

Molecular Function

GTPase binding; Golgi to plasma membrane protein transport

Subcellular Location

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus

Expression

Homodimer. Interacts with GTP bound ARL1. Interacts with MACF1.

Structure

Extended rod-like protein with coiled-coil domains. Ctonains 1 GRIP domain.

Alternative Nomenclature

256 kDa golgin antibody

72.1 protein antibody

GCP2 antibody

GOLG antibody

GOLGA4 antibody

Golgin subfamily A member 4 antibody

golgin-240 antibody

Golgin-245 antibody

MU-RMS-40.18 antibody

p230 antibody

Protein 72.1 antibody

Trans-Golgi p230 antibody

General Information

Product

Golgin A3 Antibody

Description

Affinity Purified Golgin subfamily A member 3 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Rat

Immunogen

Synthetic peptide taken within amino acid region 1400-1450 on human Golgin subfamily A member 3 isoform 1 protein.

Accession #

NCBI:  NP_005886.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q08378

Overview

Golgi auto-antigen; probably involved in maintaining Golgi structure.

Molecular Function

Transporter activity

Subcellular Location

Cytoplasm. Golgi apparatus › Golgi stack membrane; Peripheral membrane protein

Expression

Expressed in all tissues tested. Expressed in liver, testis, lung, heart, salivary gland and kidney.

Structure

Homodimer. Interacts with GOLGA7. Isoform 1 interacts with GOPC while isoform 3 does not.

Alternative Nomenclature

GCP170 antibody

GOLGA 3 antibody

Golgi autoantigen antibody

Golgi complex-associated protein of 170 kD antibody

Golgi peripheral membrane protein antibody

Golgin 160 antibody

Golgin subfamily a 3 antibody

HGNC:4426 antibody

Male enhanced antigen 2 antibody

MEA2 antibody

SY2/SY10 protein antibody

General Information

Product

Golgin A2 Antibody Affinity Purified

Description

Affinity Purified Golgin subfamily A member 2 Antibody

Verified Applications

ELISA, IMM, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 925-975 on human Golgin subfamily A member 2 isoform X3 protein.

Accession #

NCBI:  XP_005251989.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

UPI000387D38E

Overview

Golgi auto-antigen; probably involved in maintaining cis-Golgi structure.

Molecular Function

Protein Kinase binding; Syntaxin binding; Mitotic Cell Cycle

Subcellular Location

Golgi apparatus › Golgi stack membrane; Peripheral membrane protein

Structure

Part of a larger oligomeric complex. Interacts with p115 (By similarity). Interacts with RAB1B that has been activated by GTP-binding. Interacts with GORASP1/GRASP65 and ZFPL1.

Alternative Nomenclature

130 kDa cis Golgi matrix protein antibody

Cis golgi matrix protein GM130 antibody

GM130 antibody

GM130 autoantigen antibody

GOLGA 2 antibody

Golgi autoantigen antibody

Golgi autoantigen golgin subfamily a 2 antibody

Golgi matrix protein GM130 antibody

Golgin 95 antibody

golgin A2 antibody

Golgin subfamily A member 2 antibody

Golgin-95 antibody

MGC20672 antibody

SY11 protein antibody