BACE2 A/C Antibody

Product no.: BACE-201AP

$285.00

Description

General Information
Product	BACE2 A/C Antibody
Description	Affinity Purified Beta Secretase beta-site APP cleaving Enzyme 2A/C Antibody
Verified Applications	ELISA, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human Predicted: Mouse, Rat
Immunogen	Synthetic peptide taken within amino acid region 490-518 on human BACE2 protein.
Specificity	This antibody will only detect BACE2A and BACE2C protein.
Accession #	GenBank: AAQ89286
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.72-0.76 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:10,000
ELISA	1:10,000
Immunohistochemistry	1:50-1:150
Immunoprecipitation	1:200
Western Blot	1:500
Protein
Uniprot #	Q9Y5Z0
Overview	Responsible for the proteolytic processing of the amyloid precursor protein. Cleaves APP between 690 and 691 leading to the generation and extracellular release of beta-cleaved soluble APP and C-terminal fragment which is later released by gamma-secretase.
Molecular Function	Aspartic-type endopeptidase activity.
Subcellular Location	Endoplasmic reticulum, Endosome, Golgi apparatus; Membrane
Expression	Neurons within the hippocampus, frontal cortex and temporal cortex. Lower expression in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Also found in spinal cord, medulla oblongata, substania nigra and locus coruleus. Expressed in ductal epithelium of prostate.
Structure	Belongs to the peptidase A1 family.
Alternative Nomenclature	ALP 56 antibody ASP1 antibody ASP21 antibody Aspartic Like Protease 56kDa antibody Downs Syndrome Region Aspartic Protease antibody DRAP antibody Memapsin-1 antibody Membrane associated aspartic protease 1 antibody Theta-secretase antibody

Protein information supplied by UniProt