General Information
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Product
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MAPK6 Antibody
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Description
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Affinity Purified Mitogen-activated protein kinase 6 Antibody
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Verified Applications
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ELISA, IP, WB
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Host
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Chicken
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic peptide taken within amino acid region 480-530 on human Mitogen-activated protein kinase 6.
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.5 µg/µl in antibody stabilization buffer
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Immunoglobulin
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IgY
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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ELISA
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1:10,000
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Immunoprecipitation
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1:150
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Western Blot
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1:500
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Protein
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Uniprot #
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Q16659
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Overview
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Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle.
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Molecular Function
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Kinase, Serine/threonine-protein kinase, Transferase
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Subcellular Location
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Cytoplasm, Nucleus
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Expression
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Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts.
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Structure
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In contrast to classical MAPKs, the TXY motif within the activation loop is replaced by the SEG motif, whose phosphorylation activates the MAP kinases.
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Alternative Nomenclature
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ERK3 antibody
Extracellular signal regulated kinase p97 antibody
Extracellular signal-regulated kinase 3 antibody
HsT17250 antibody
MAP kinase 6 antibody
MAP kinase isoform p97 antibody
Mitogen activated protein kinase 6 antibody
p97 MAPK antibody
PRKM6 antibody
Protein kinase mitogen activated 6 antibody
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