PERK Antibody

Product no.: PERK-101AP
$295.00
$265.00


General Information

 

 

Product

 

PERK Antibody

Description

Affinity Purified Eukaryotic translation initiation factor 2-alpha kinase 3 Antibody

Verified Applications

DB, ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1000-1050 on human Eukaryotic translation initiation factor 2-alpha kinase 3 protein.

Accession #

NCBINP_004827


Physical Properties

 

 

Quantity

 

100 µg

Volume

200 µl

Concentration

0.68-0.70 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20C for long term storage


Application Protocol

Dot Blot

1:4,000

ELISA

1:4,000

Immunohistochemistry 1:50-1:100

Immunoprecipitation

1:150

Western Blot

1:500


Protein

 

Uniprot #

 

Q9NZJ5

Overview

Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.

Molecular Function

Kinase, Serine/threonine-protein kinase, Transferase

Subcellular Location

Endoplasmic reticulum membrane; Single-pass type I membrane protein

Expression

Ubiquitous. A high level expression is seen in secretory tissues.

Structure

Forms dimers with HSPA5/BIP in resting cells. Oligomerizes in ER-stressed cells. Interacts with DNAJC3 and MFN2.

Alternative Nomenclature

Eif2ak3 antibody

Eukaryotic translation initiation factor 2 alpha kinase 3 antibody

Heme regulated EIF2 alpha kinase antibody

HRI antibody

HsPEK antibody

Pancreatic eIF2 alpha kinase antibody

PEK antibody

PRKR like endoplasmic reticulum kinase antibody

WRS antibody

   

Protein information supplied by UniProt

Accessories

Product Note Status Price
PERK Antibody BIOTIN PERK Antibody BIOTIN
PERK-BIOTIN $350.00 *
PERK Antibody FITC PERK Antibody FITC
PERK-FITC $350.00 *
PERK Blocking Peptide PERK Blocking Peptide
P-PERK $145.00 *
PERK Positive Control PERK Positive Control
PC-PERK $185.00 *
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