PTIP Antibody

General Information

Product

PTIP Antibody

Description

Affinity Purified PAX-interacting protein 1 Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1000-1069 on human PTIP protein.

Accession #

NCBI:  NP_031375

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.60-0.62 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DOT Blot

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q6ZW49

Overview

Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. Plays a role in early development. In DNA damage response is required for cell survival after ionizing radiation. In vitro shown to be involved in the homologous recombination mechanism for the repair of double-strand breaks (DSBs).

Subcellular Location

Nucleus matrix

Structure

Interacts with the C-terminal transactivation domain of PAX2 (By similarity). Interacts with PAGR1; the interaction is direct and also occurs independent of MLL-containing complexes. Interacts with TP53BP1 (phosphorylated at 'Ser-25').

Alternative Nomenclature

CAGF 28 antibody

CAGF 29 antibody

PACIP1 antibody

PAX-interacting protein 1 antibody

Protein encoded by CAG trinucleotide repeats antibody

PTIP antibody

TNRC2 antibody