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General Information
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Product
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PTIP Antibody BIOTIN
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Description
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BIOTIN-Conjugated PAX-interacting protein 1 Antibody
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Verified Applications
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CM, ELISA, ICC, IF, IHC, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic peptide taken within amino acid region 1000-1069 on human PTIP protein.
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Accession #
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NCBI: NP_031375
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.60-0.62 µg/µl in antibody stabilization buffer
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Form
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BIOTIN-Conjugated
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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Confocal Microscopy
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1:200
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DB
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1:10,000
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ELISA
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1:10,000
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Immunocytochemistry
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1:200
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Immunofluorescence
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1:200
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Immunohistochemistry
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1:200
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Immunoprecipitation
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1:200
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Western Blot
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1:500
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Protein
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Uniprot #
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Q6ZW49
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Overview
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Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. Plays a role in early development. In DNA damage response is required for cell survival after ionizing radiation. In vitro shown to be involved in the homologous recombination mechanism for the repair of double-strand breaks (DSBs).
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Subcellular Location
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Nucleus matrix
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Structure
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Interacts with the C-terminal transactivation domain of PAX2 (By similarity). Interacts with PAGR1; the interaction is direct and also occurs independent of MLL-containing complexes. Interacts with TP53BP1 (phosphorylated at 'Ser-25').
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Alternative Nomenclature
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CAGF 28 antibody
CAGF 29 antibody
PACIP1 antibody
PAX-interacting protein 1 antibody
Protein encoded by CAG trinucleotide repeats antibody
PTIP antibody
TNRC2 antibody
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PTIP Blocking Peptide
PTIP Antibody
PTIP Antibody FITC
PTIP Positive Control
