Presenilin 2 Antibody

Product no.: PSEN-201AP

$285.00

Description
QA_1

1_11

General Information
Product	Presenilin 2 Antibody Affinity Purified
Description	Affinity Purified Presenilin-2 isoform 1 Antibody N-epitope
Verified Applications	ELISA, IMM, WB
Host	Rabbit
Species Cross Reactivity	Human, Monkey, Rat
Immunogen	Synthetic peptide taken within amino acid region 1-50 on human Presenilin-2 protein.
Accession #	NCBI: NP_036618
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	1.00-1.25 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Determinant	N-epitope
Storage	-20⁰C for long term storage
Application Protocol
DB	1:10,000
ELISA	1:10,000
Immunoprecipitation	1:150
Western Blot	1:500
Protein
Uniprot #	P49810
Overview	Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane.
Molecular Function	Hydrolase, Protease, aspartic-type endopeptidase activity
Subcellular Location	Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein
Expression	Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney.
Structure	Interacts with DOCK3 (By similarity). Homodimer. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase a
Alternative Nomenclature	AD 3LP antibody AD 4 antibody AD 5 antibody Alzheimer disease 4 antibody CMD1V antibody E5 1 antibody Presenilin 2 (Alzheimer disease 4) antibody PS2 antibody PSEN 2 antibody STM2 antibody

Protein information supplied by UniProt