SIGLEC10 Blocking Peptide

General Information

Product

SIGLEC10 Peptide

Description

Antigenic Blocking Peptide Sialic acid-binding Ig-like lectin 10 Antibody

Verified Applications

Immunocompetition, Immunodepletion

Peptide Description

Synthetic peptide taken within amino acid region 650-697 on human SIGLEC10 protein.

Accession #

NCBI:  NP_149121.2

Physical Properties

Quantity

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Storage

-20⁰C for long term storage

Application Protocol

Competition/Depletion assay

Refer to competition assay protocol

Protein

Uniprot #

Q96LC7

Overview

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Molecular Function

carbohydrate binding

Subcellular Location

Isoform 1,2,3,4: cell membrane, single-pass type I membrane protein; isoform 5: secreted

Expression

Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation). Isoform5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and appendix. Isoform 1 is found  high levels and isoform 2 at lower levels in bone marrow, spleen and spinal chord. Isoform 2 is also found in brain. Isoform 4 is specifically found in natural killer cells.

Alternative Nomenclature

mSiglec G antibody,

PRO940 antibody,

Sialic acid binding Ig like lectin 10 antibody,

sialic acid binding Ig like lectin G antibody,

Sialic acid-binding Ig-like lectin 10 antibody,

Siglec G antibody,

Siglecg antibody,

SLG2 antibody