Sequestosome-1 Positive Control

Product no.: PC-SQSTM
$200.00


General Information

 

 

Product

 

SQSTM1 / p62 Positive Control

Verified Applications

WB


Physical Properties

 

 

Quantity

 

5 Applications

Volume

Inquire

Form

Western Blot Positive Control

Concentration The concentration of the sample is empirically set so that 20 µl per lane in Western and blotted with corresponding affinity purified antibody will give a clean band with a high signal to noise ratio on the gel.

Storage

-20C for long term storage


Application Protocol

Western Blot

1:500


Protein

 

Uniprot #

 

Q13501

Overview

Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD. May be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels.

Molecular Function

identical protein binding, protein kinase binding, protein kinase C binding, protein serine/threonine kinase activity, receptor tyrosine kinase binding, SH2 domain binding, ubiquitin binding, ubiquitin protein ligase binding, zinc ion binding

Subcellular Location

Cytoplasm

Late endosome

Lysosome

Cytoplasmic vesicle › autophagosome

Nucleus

Endoplasmic reticulum

Cytoplasm › P-body

Expression

Ubiquitously expressed.

Structure

Homooligomer or heterooligomer; may form homotypic arrays. Dimerization interferes with ubiquitin binding.

Alternative Nomenclature

A170 antibody

EBI 3 associated protein of 60 kDa antibody

EBIAP antibody

FTDALS3 antibody

ORCA antibody

OSF-6 antibody

Osi antibody

OSIL antibody

Oxidative stress induced like antibody

p60 antibody

p62 antibody

p62B antibody

Paget disease of bone 3 antibody

PDB3 antibody

Phosphotyrosine independent ligand for the Lck SH2 domain of 62 kDa antibody

PKC-zeta-interacting protein antibody

Protein kinase C-zeta-interacting protein antibody

Sequestosome 1 antibody

SQSTM 1 antibody

STAP antibody

STONE14 antibody

Ubiquitin-binding protein p62 antibody

ZIP antibody

ZIP3 antibody

   

Protein information supplied by UniProt
 

 

Accessories

Product Note Status Price
SQSTM1 / p62 Antibody SQSTM1 / p62 Antibody
SQSTM-101AP $285.00 *
Sequestosome-1 Antibody BIOTIN Sequestosome-1 Antibody BIOTIN
SQSTM-BIOTIN $375.00 *
SQSTM1 / p62 Antibody FITC SQSTM1 / p62 Antibody FITC
SQSTM-FITC $375.00 *
SQSTM1 / p62 Blocking Peptide SQSTM1 / p62 Blocking Peptide
P-SQSTM $155.00 *
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