General Information
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Product
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ZFP36L2 Peptide
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Description
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Antigenic Blocking Peptide Zinc finger protein 36, C3H1 type-like 2 Antibody
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Verified Applications
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Immunodepletion, Immunocompetition
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Peptide Description
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Synthetic peptide taken within amino acid reigon 350-400 on human Zinc finger protein 36, C3H1 type-like 2.
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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P47974
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Overview
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mRNA-binding protein that plays a key role in self-renewal of erythroid cells in response to glucocorticoids. Specifically binds to the AU-rich element (ARE) in the 3'-UTR of target mRNAs, promoting their deadenylation and degradation (PubMed:14981510). Specifically expressed in burst-forming unit-erythroid (BFU-E) progenitors in response to glucocorticoids and acts as a negative regulator of erythroid cell differentiation: promotes self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. Down-regulated during erythroid differentiation from the BFU-E stage, stabilizing mRNAs required for terminal differentiation.
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Molecular Function
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AU-rich element binding, DNA binding, metal ion binding, mRNA 3'-UTR AU-rich region binding, poly(A) RNA binding, transcription factor activity, sequence-specific DNA binding
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Subcellular Location
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Cytoplasm, Nucleus
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Structure
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Repeat, Zinc-finger
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Alternative Nomenclature
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BRF2 antibody
Butyrate response factor 2 antibody
C3H1 type-like 2 antibody
EGF response factor 2 antibody
ERF 2 antibody
Protein TIS11D antibody
RNF162C antibody
TIS11D antibody
ZFP36 like 2 antibody
ZFP36 ring finger protein like 2 antibody
Zinc finger protein 36 antibody
Zinc finger protein 36, C3H type like 1 antibody
zinc finger protein 36, C3H type like 2 antibody
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