FGFR4 Antibody


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FGFR4 Antibody

Product no.: FGFR4-401AP
$295.00
$265.00


General Information

 

 

Product

 

FGFR4 Antibody

Description

Affinity Purified Fibroblast growth factor receptor 4 variant Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 520-570 on human Fibroblast growth factor receptor 4 variant protein.

Accession #

GenBank: AAK51435


Physical Properties

 

 

Quantity

 

100 µg

Volume

200 µl

Concentration

0.55 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20C for long term storage


Application Protocol

 

ELISA

 

1:10,000

Immunoprecipitation

1:150

Immunohistochemistry 1:50-1:100

Western Blot

1:500


Protein

 

Uniprot #

 

P22455

Overview

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. 

Molecular Function

ATP-binding; Fibroblast growth factor binding; Heparin binding; Protein Tyrosine Kinase activity

Subcellular Location

Cell membrane; Single-pass type I membrane protein. Endosome. Endoplasmic reticulum

Expression

Expressed in gastrointestinal epithelial cells, pancreas, and gastric and pancreatic cancer cell lines.

Structure

Monomer. Homodimer after ligand binding. Interacts with FGF1, FGF2, FGF4, FGF6, FGF8, FGF9, FGF16, FGF17, FGF18, FGF19, FGF21 and FGF23 (in vitro). Binding affinity for FGF family members is enhanced by interactions between FGFs and heparan sulfate proteoglycans. Interacts with KLB; this strongly increases the affinity for FGF19 and FGF23. Affinity for FGF19 is strongly increased by KLB and sulfated glycosaminoglycans. KLB and KL both interact with the core-glycosylated FGFR4 in the endoplasmic reticulum and promote its degradation, so that only FGFR4 with fully mature N-glycans is expressed at the cell surface. Identified in a complex with NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with MMP14 and HIP1.

Alternative Nomenclature

CD334 

fc13h10 

FGFR-4 

Fibroblast growth factor receptor 4 

Hydroxyaryl protein kinase 

JTK 2 

Protein tyrosine kinase 

TKF 

Tyrosine kinase related to fibroblast growth factor receptor 

Tyrosylprotein kinase 

   

Protein information supplied by UniProt
 

 

Accessories

Product Note Status Price
FGFR4 Antibody FITC FGFR4 Antibody FITC
FGFR4-FITC $350.00 *
FGFR4 Antibody BIOTIN FGFR4 Antibody BIOTIN
FGFR4-BIOTIN $350.00 *
FGFR4 Blocking Peptide FGFR4 Blocking Peptide
P-FGFR4 $145.00 *
FGFR4 Positive Control FGFR4 Positive Control
PC-FGFR4 $185.00 *
Display accessory details

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Browse these categories as well: FGF Receptors, FGF Receptors, Lineage Markers, Cell markers & CAMs, Surface Molecules, Primaries, Receptor Tyrosine Kinases
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