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General Information
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Product
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ACK1 Antibody
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Description
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Affinity Purified Activated CDC42 kinase 1 Antibody
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Verified Applications
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ELISA, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic peptide taken within amino acid region 250-300 on ACK1 protein.
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Accession #
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GenBank:
AAA53570.2
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.59-0.68 µg/µl in antibody stabilization buffer
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Immunoglobulin
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IgG
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Form
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Affinity Purified
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Purification Method
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Immobilized antigen affinity chromatography
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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ELISA
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1:10,000
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Immunoprecipitation
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1:200
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Western Blot
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1:500
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Protein
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Uniprot #
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Q07912
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Overview
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Non-receptor tyrosine-protein and serine/threonine-protein kinase implicated in cell sperading and migration, survival, growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors.
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Molecular Function
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ATP binding; epidermal growth factor receptor binding; GTPase inhibitor activity; non-membrane spanning protein tyrosine kinase activity; protein serine/threonine kinase activity
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Subcellular Location
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Cell membrane; Nucleus; Endosome; Cell junction; adherens junction; Cytoplasmic vessicle membrane; Peripheral membrane protein; Clathrin-coated vessicles; Clathin coated pit
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Expression
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During progressive stages in breast and prostate cancer
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Structure
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Forms complexes with GRB2 and several receptor tyrosine kinases. Part of collagen stimulated complex.
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Alternative Nomenclature
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Acetate kinase 1 antibody
Acetokinase 1 antibody
ACK 1 antibody
Activated Cdc42 associated kinase 1 antibody
Activated CDC42 kinase 1 antibody
Activated p21cdc42Hs kinase antibody
p21cdc42Hs antibody
TNK 2 antibody
Tyrosine kinase non-receptor protein 2 antibody
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ACK1 Antibody FITC
ACK1 Antibody BIOTIN
ACK1 Blocking Peptide
ACK1 Positive Control
