AGE Antibody


AGE Antibody

Product no.: AGE-101AP
$295.00
$265.00


General Information

 

 

Product

 

AGE Antibody

Description

Affinity Purified Advance Glycated Endproduct Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Monkey, Panda

Immunogen

Purified glycated ribonuclease corresponding to AGE. Glycated ribonuclease (RNase) prepared by incubating RNase with glucose at 37C for several months.


Physical Properties

 

 

Quantity

 

100 µg

Volume

200 µl

Concentration

0.55 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20C for long term storage


Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500


Protein

Overview

Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators.

Molecular Function

Inflammatory Response

Subcellular Location

Isoform 1 : Cell membrane; Single-pass type I membrane protein

Isoform 2 : Secreted

Isoform 10 : Cell membrane 1 Publication; Single-pass type I membrane protein

Expression

Endothelial cells.

Structure

Interacts with S100A1 and APP (By similarity). Interacts with S100B, S100A12 and S100A14. Constitutive homodimer; disulfide-linked.

Alternative Nomenclature

Advanced glycation end products antibody

AGEs antibody

   

Protein information supplied by UniProt
 

Accessories

Product Note Status Price
AGE Antibody FITC AGE Antibody FITC
AGE-FITC $350.00 *
AGE Antibody BIOTIN AGE Antibody BIOTIN
AGE-BIOTIN $350.00 *
AGE Blocking Peptide AGE Blocking Peptide
P-AGE $145.00 *
AGE Positive Control AGE Positive Control
PC-AGE $185.00 *
Display accessory details

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