Angiopoietin-like 4 Antibody

Product no.: ANGPTL4-101AP

$285.00

Description

General Information
Product	Angiopoietin-like 4 Antibody
Description	Affinity Purified Angiopoietin-related protein 4 Antibody
Verified Applications	ELISA, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Mouse
Immunogen	Synthetic peptide taken within amino acid region 50-100 on mouse Angiopoietin-related protein 4.
Accession #	NCBI: NP_065606.2
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.5-1.5 µg/µl in antibody stabilization buffer
Immunoglobulin	IgG
Form	Affinity Purified
Purification Method	Immobilized antigen affinity chromatography
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
ELISA	1:50,000
Immunohistochemistry	1:50-1:150
Immunoprecipitation	1:200
Western Blot	1:2,500-1:5,000
Protein
Uniprot #	Q9Z1P8
Overview	Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity (By similarity). In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.
Molecular Function	enzyme inhibitor activity identical protein binding
Subcellular Location	Secreted
Expression	Predominantly expressed in adipose tissue and is strongly up-regulated by fasting in white adipose tissue and liver.
Structure	Coiled coil, Signal
Alternative Nomenclature	Angiopoietin like 4 antibody Angiopoietin-like protein 4 antibody ANGPT L2 antibody ANGPT L4 antibody Angptl4 antibody ARP4 antibody Fasting induced adipose factor antibody FIAF antibody HARP antibody Hepatic angiopoietin related protein antibody Hepatic fibrinogen/angiopoietin-related protein antibody HFARP antibody NL2 antibody Peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin related protein antibody PGAR antibody pp1158 antibody PPARG angiopoietin related protein antibody PSEC0166 antibody TGQTL antibody UNQ171 antibody Weakly similar to angiopoietin 1 [H.sapiens] antibody

Protein information supplied by UniProt.