Aph 1b Antibody

Product no.: APH1B-101AP

$285.00

Description

General Information
Product	Aph 1b Antibody
Description	Affinity Purified Presenelin-stabiliziation factor-like Antibody
Verified Applications	ELISA, WB
Host	Rabbit
Species Cross Reactivity	C. elegans, Human, Mouse, Rat
Immunogen	Synthetic peptide taken within amino acid region 235-257 of Human Presenilin stabilizing protein.
Specificity	APH1B-101AP does not cross react to other component of gamma secretase complex nor with other proteins.
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.6 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:10,000
ELISA	1:10,000
Western Blot	1:500
Protein
Uniprot #	Q8WW43
Overview	Subunit of gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and beta-amyloid precursor protein.
Molecular Function	Notch signaling pathway
Subcellular Location	Membrane; Multi-pass protein
Expression	Weakly expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, skeletal muscle, heart, and brain.
Structure	Component of gamma-secretase complex. Interacts with PSEN1 and PSEN2.
Alternative Nomenclature	Anterior pharynx defective 1B like antibody Gamma secretase subunit APH 1B antibody Presenilin stabilisation factor like antibody PRO1328 antibody PSFL antibody TAAV 688 antibody

Protein information supplied by UniProt