General Information
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Product
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ATG16L1 Antibody
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Description
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Affinity Purified Autophagy-related protein 16-1 Antibody
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Verified Applications
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ELISA, IHC, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Mouse, Rat
Predicted: Human
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Immunogen
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Synthetic peptide taken within amino acid region 560-610 on human Autophagy-related protein 16-1.
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.5 µg/µl in antibody stabilization buffer
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Immunoglobulin
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IgG
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Form
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Affinity Purified
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Purification Method
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Immobilized antigen affinity chromatography
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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ELISA
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1:10,000
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Immunohistochemistry |
1:50-1:150 |
Immunoprecipitation
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1:150
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Western Blot
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1:500
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Protein
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Uniprot #
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Q676U5
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Overview
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Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane.
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Molecular Function
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Identical protein binding, Ubiquitin-like protein transferase activity
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Subcellular Location
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Cytoplasm, Preautophagosomal structure membrane, Peripheral membrane protein
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Structure
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Homooligomer. Interacts with WIPI2, FIP200 and ATG5. Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa). Interacts with RAB33B. Interacts with TMEM
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Alternative Nomenclature
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APG16 like 1 antibody
APG16L antibody
APG16L beta antibody
ATG16 autophagy related 16 like 1 antibody
ATG16A antibody
ATG16L antibody
Autophagy related protein 16 1 antibody
IBD10 antibody
WD repeat domain 30 antibody
WDR30 antibody
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