Bcl6 Antibody

Product no.: BCL6-631AP

$285.00

Description

General Information
Product	Bcl6 Antibody
Description	Affinity Purified B-Cell lymphoma 6 protein Antibody Mid-region
Verified Applications	ELISA, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Monkey, Mouse, Rat
Immunogen	Synthetic peptide taken within amino acid region 200-250 on human B-cell lymphoma protein isoform 1.
Accession #	NCBI: NP_001124317
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.5 µg/µl in antibody stabilization buffer
Immunoglobulin	IgG
Form	Affinity Purified
Purification Method	Immobilized antigen affinity chromatography
Clonality	Polyclonal
Determinant	Mid-region
Storage	-20⁰C for long term storage
Application Protocol
ELISA	1:10,000
Immunoprecipitation	1:150
Western Blot	1:500
Protein
Uniprot #	P41182
Overview	Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors.
Molecular Function	Chromatin Binding; Actin Cytoskeleton organization; Cellular response to DNA damage stimulus; Negative regulation of cell growth; Activator; Repressor
Subcellular Location	Nucleus
Expression	Expressed in germinal center T- and B-cells and in primary immature dendritic cells.
Structure	Homodimer.
Alternative Nomenclature	B cell CLL/lymphoma 6 antibody Bcl 6 antibody BCL-5 antibody BCL-6 antibody cys his2 zinc finger transcription factor antibody LAZ 3 antibody Lymphoma associated zinc finger gene on chromosome 3 antibody Protein LAZ-3 antibody ZBTB 27 antibody Zinc finger and BTB domain-containing protein 27 antibody Zinc finger protein 51 antibody zinc finger transcription factor BCL6S antibody ZNF 51 antibody

Protein information supplied by UniProt.