BMPR1A Antibody

General Information

Product

BMPR1A Antibody

Description

Affinity Purified Bone morphogenetic protein receptor type-1A Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 460-510 on human Bone morphogenetic protein receptor type-1A.

Accession #

NCBI:  NP_004320

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

P36894

Overview

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6.

Molecular Function

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Subcellular Location

Membrane; Single-pass type I membrane protein

Expression

Highly expressed in skeletal muscle.

Structure

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Contains 1 GS domain.

Contains 1 protein kinase domain.

Alternative Nomenclature

Activin A receptor type II like kinase 3 

Activin receptor like kinase 3 

ACVRLK 3

ALK 3 

BMP type-1A receptor 

BMPR 1A 

Bmpr 

Bone morphogenetic protein receptor type-1A

BR1a

CD292 

Serine threonine protein kinase receptor R5

SKR5 

zBMPR IA