General Information
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Product
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BMPR1A Antibody
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Description
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Affinity Purified Bone morphogenetic protein receptor type-1A Antibody
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Verified Applications
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ELISA, IHC, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic peptide taken within amino acid region 460-510 on human Bone morphogenetic protein receptor type-1A.
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Accession #
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NCBI: NP_004320
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.5 µg/µl in antibody stabilization buffer
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Immunoglobulin
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IgG
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Form
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Affinity Purified
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Purification Method
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Immobilized antigen affinity chromatography
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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ELISA
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1:10,000
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Immunohistochemistry |
1:150 |
Immunoprecipitation
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1:150
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Western Blot
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1:500
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Protein
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Uniprot #
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P36894
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Overview
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On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6.
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Molecular Function
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Kinase, Receptor, Serine/threonine-protein kinase, Transferase
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Subcellular Location
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Membrane; Single-pass type I membrane protein
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Expression
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Highly expressed in skeletal muscle.
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Structure
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Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 GS domain.
Contains 1 protein kinase domain.
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Alternative Nomenclature
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Activin A receptor type II like kinase 3
Activin receptor like kinase 3
ACVRLK 3
ALK 3
BMP type-1A receptor
BMPR 1A
Bmpr
Bone morphogenetic protein receptor type-1A
BR1a
CD292
Serine threonine protein kinase receptor R5
SKR5
zBMPR IA
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