Sialoadhesin Antibody

Product no.: CD169-101AP

Description

General Information
Product	Sialoadhesin Antibody
Description	Affinity Purified CD169 Antibody
Verified Applications	ELISA, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Monkey
Immunogen	Synthetic peptide taken within amino acid region 10-60 on human Sialoadhesin protein.
Accession #	NCBI: NP_075556
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.5 µg/µl in antibody stabilization buffer
Immunoglobulin	IgG
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
ELISA	1:10,000
Immunohistochemistry	1:50-1:150
Immunoprecipitation	1:200
Western Blot	1:500
Protein
Uniprot #	Q9BZZ2
Overview	Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells.Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hemopoiesis.
Molecular Function	Carbohydrate binding; Cell adhesion; Endocytosis
Subcellular Location	Isoform 1: Cell membrane; Isoform 2: Secreted
Expression	Expressed by macrophages in various tissues. High levels are found in spleen, lymph node, perivascular macrophages in brain and lower levels in bone marrow, liver Kupffer cells and lamina propria of colon and lung. Also expressed by inflammatory macrophagrophages in rheumatoid arthritis.
Structure	Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. Contains 16 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Alternative Nomenclature	CD169 antibody sialic acid binding Ig-like lectin 1, sialoadhesin antibody Sialic acid-binding Ig-like lectin 1 antibody Sialoadhesin antibody Siglec 1 antibody SN antibody

Protein information supplied by UniProt