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General Information
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Product
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CRMP2 Antibody
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Description
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Affinity Purified Collapsin response mediated protein 2 Antibody
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Verified Applications
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ELISA, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic peptide taken from within the region corresponding to AA 60-115 of the CRMP2 protein. The 26mer peptide was conserved in several other species. The selected peptide was post-synthetically modified to achieve highest antigenicity before coupling to carrier protein using hetero-bifunctional cross linker for immunogen preparation.
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Accession #
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NCBI: NP_001184222.1
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.57 µg/µl in antibody stabilization buffer
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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| Storage buffer |
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: Tris glycine, Tris HCl, 30% Glycerol, 0.5% BSA, HEPES
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Application Protocol
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DB
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1:10,000
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ELISA
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1:10,000
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Western Blot
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1:500. Detects a band of approximately 64 kDa in PC-CRMP2 samples. In Jurkat cells, the antibody labels a smaller band (MW 54-56 kDa), the identity of this protein is not known, but may represent a splice variant or proteolysis product of CRMP2 protein.
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Protein
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Uniprot #
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Q16555
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Overview
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Involved in neuronal development and polarity, axon growth and guidance, neuronal growth cone collapse, and cell migration. Is needed for signalling by class 3 semaphorins and later remodeling of the cytoskeleton.
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Molecular Function
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Dihydropyrimidinase activity; developmental protein
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Subcellular Location
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Cytoplasm; Cytoskeleton; Membrane
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Expression
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Ubiquitous
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Structure
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Homotetramer and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5. Intteracts via its C-terminus with the C-terminus of CYF1P1/SRA1. Also interacts with HTR4, CLN6 and MICALL1.
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Alternative Nomenclature
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CRAM antibody
DHPRP 2 antibody
Dihydropyrimidinase 2 antibody
DPYL 2 antibody
Musunc 33 antibody
N2A3 antibody
TOAD 64 antibody
ULIP 2 protein antibody
Unc-33-like phosphoprotein 2 antibody
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CRMP2 Antibody FITC
CRMP2 Antibody BIOTIN
CRMP2 Blocking Peptide
CRMP2 Positive Control
