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General Information
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Product
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beta Catenin Antibody
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Verified Applications
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ELISA, IHC, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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N-epitope synthetic peptide taken within amino acid region 50-100 on human beta CTNNB protein.
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.57 µg/µl in antibody stabilization buffer
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Determinant
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N-epitope
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Storage
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-20⁰C for long term storage
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Application Protocol
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Dot Blot
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1:10,000
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ELISA
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1:10,000
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| Immunohistochemistry |
1:50-1:100 |
| Immunoprecipitation |
1:150 |
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Western Blot
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1:500
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Protein
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Uniprot #
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P35222
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Overview
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Major downstream component of the canonical Wnt signalling pathway. Also involved in the regulation of cell adhesion and acts as a negative regulator of centrosome cohesion.
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Molecular Function
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Activator; Alpha-catenin binding; Cadherin binding; signal transducer activity
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Subcellular Location
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Cytoplasm; Nucleus; Cell junction; Cell Membrane
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Expression
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Expressed in hair follicle cell types including basal and peripheral matrix cells as well as cells of the outer and inner root sheaths. Also expressed in colon and is present in cortical neurons at protein level.
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Structure
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Two separate complex associated pools found in cytoplasm, majority as compenent of an E-cadheren/catenin adhesion complex. Another cytoplasmic pool is a part of a large complex which holds AXIN1, AXIN2, APC, CSNK1A1 and GSK3B
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Alternative Nomenclature
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Cadherin associated protein antibody
Catenin (cadherin associated protein), beta 1, 88kDa antibody
CATNB antibody
CHBCAT antibody
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beta Catenin Antibody FITC
beta Catenin Antibody BIOTIN
beta Catenin Blocking Peptide
beta Catenin Positive Control
